Activation of Nuclear Factor κB in Single Living Cells
نویسندگان
چکیده
منابع مشابه
Tumor necrosis factor-α induces transcriptional activation of nuclear factor-κB in insulin-producing β-cells.
We previously showed that tumor necrosis factor-α (TNF-α) induces the dysregulation of intracellular calcium [Ca(2+)](i) in β-cells by decreasing the levels of the cytoplasmic Ca(2+) binding protein calbindin-D(28k). The purpose of the present study was to test the hypothesis that TNF-α-induced dysregulation of [Ca(2+)](i) in insulin-producing β-cells causes proteolytic degradation of IκBα and ...
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3 4 Authors: Steven K. Malin1,2, John P. Kirwan1,2, Chang Ling Sia3, and Frank González3 5 6 7 1Dept. of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; 8 2Dept. of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH; 9 3Dept. of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN. 10 11 12 13 14 Funding: Nationa...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.53.37941